[影响肝癌异种移植的瘤性因素]
1Beijing Institute of Hepatology, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
概括
建立肝癌患者衍生异种移植 (PDX) 模型显示,高病理级和Ki67表达显著影响瘤性. 这项研究有助于理解PDX模型中的肝癌进展.
科学领域:
- 在瘤学瘤学.
- 翻译医学是一种翻译医学.
- 动物模型 动物模型
背景情况:
- 患者衍生异种移植 (PDX) 模型对于研究人类癌症至关重要.
- 建立可靠的肝癌PDX模型对于临床前研究至关重要.
- 了解影响PDX模型成功的因素是有效药物开发的关键.
研究的目的:
- 从肝癌患者中开发PDX模型.
- 在PDX模型中识别影响肝癌瘤性因素.
主要方法:
- 肝细胞癌组织被注射到NPG小鼠中,以创建PDX模型.
- 来自60名患者的临床数据和来自24个样本的基因组数据被收集和分析.
- 使用SPSS 17.0.0.进行了统计分析,包括奇二测试.
主要成果:
- 在PDX模型中,瘤发生率达到35% (21/60).
- 埃德蒙森等级和Ki67表达显示了瘤原生和非瘤原生PDX样本之间的显著差异 (P<0.05).
- 在瘤原生和非瘤原生PDX样本之间没有观察到TOP25基因突变的显著差异.
结论:
- 在PDX模型中,肝癌的瘤性受复杂因素的影响.
- 高病理级和强大的Ki67表达是成功建立肝癌PDX模型的关键决定因素.
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