非类固醇抗炎药物,血液代谢物和结石:一个全面的门德尔随机化研究
Hao Yu1,2, Feng Zeng1,2, Jian Wu1,2
1Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Urolithiasis
|April 24, 2025
概括
使用非类固醇抗炎药物 (NSAID) 可能因果性地增加结石风险. 某些血液代谢物,如β-hydroxyisovaleroylcarnitine,部分调解这种关联,这表明需要对高危患者进行监测.
科学领域:
- 药物基因组学 药物基因组学
- 代谢学 代谢学 代谢学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 非类固醇抗炎药物 (NSAID) 使用与结石形成之间的关联尚不清楚.
- 调查潜在的因果关系和调解因素对于患者安全至关重要.
研究的目的:
- 为了确定NSAID药物使用对结石风险的因果关系.
- 为了确定可能调解NSAID使用和结石之间的关系的血液代谢物.
主要方法:
- 使用来自FinnGen联盟的遗传数据进行了两样本的门德尔随机化 (MR) 分析.
- 遗传变异作为NSAID使用和血液代谢物的工具变量.
- 使用逆方差加权 (IVW) 方法和调度分析.
主要成果:
- 使用NSAID与结石风险增加有显著的因果关系 (OR:1.70).
- 67种血液代谢物与结石风险有因果关系.
- 使用NSAID与三种代谢物有因果关系,β-hydroxyisovaleroylcarnitine部分调解了这种作用 (5.6%).
结论:
- 使用NSAID药物可能与患结石的风险更高存在因果关系.
- 血液代谢物,特别是β-hydroxyisovaleroylcarnitine,可能在这种关联中发挥中介作用.
- 建议在NSAID治疗期间监测代谢物水平,对于容易患结石的人来说.
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