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Updated: May 10, 2025

Zebrafish Model of Neuroblastoma Metastasis
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Published on: March 14, 2021

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MYCN和KAT2A形成了一个前循环,以驱动神经母细胞瘤中的瘤转录程序

Zhihui Liu1, Jason J Hong2, Xiyuan Zhang2

  • 1Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA. liuzhihu@mail.nih.gov.

Oncogenesis
|April 24, 2025
PubMed
概括

MYCN驱动神经母细胞瘤恶性瘤. 我们发现MYCN与KAT2A合作,形成了促进癌症生长的前循环. 用PROTACs向KAT2A降低了MYCN并抑制了神经母细胞瘤细胞增殖,提供了一个新的治疗策略.

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