在健康和精神分裂症中的形态相似性网络的异质性
Joost Janssen1,2, Ana Guil Gallego3, Covadonga Martínez Díaz-Caneja3,4,5
1Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain. joost.janssen76@gmail.com.
Schizophrenia (Heidelberg, Germany)
|April 24, 2025
概括
结构性网络连接可能表明慢性精神分裂症. 这项研究发现患者默认模式网络的形态相似性有所减少,但大多数精神分裂症患者的异常并没有随着时间的推移持续存在.
科学领域:
- 神经成像是一种神经成像.
- 精神疾病 精神疾病
- 生物标志物 生物标志物
背景情况:
- 结构性网络连接性减少是慢性精神分裂症的一个拟议生物标志物.
- 皮层区域间连接对于大脑功能至关重要.
研究的目的:
- 评估区域形态学相似性作为慢性精神分裂症皮质区域间连接的指标.
- 用纵向规范模型评估精神分裂症患者之间连接性下降的一致性.
主要方法:
- 经过训练和验证的规范模型使用来自4310个健康对照的数据.
- 在基线和随访时测量了与规范 (低于正常,正常,超正常) 的个体偏差.
- 在个体内,随着时间的推移,评估了下正常或超正常区域的变化.
主要成果:
- 与对照组相比,精神分裂症患者在基线时在默认模式网络内表现出较少的形态相似性.
- 很少有 (<6%) 患者在两个时间点表现出持续的正常值以下或正常值以上,与对照组相似.
- 在患者和对照人群之间,没有发现患者和对照人群之间的下或上正常区域随时间变化的显著差异.
结论:
- 使用纵向数据的规范建模可以识别精神分裂症中的静态和动态形态度相似性异常.
- 这些发现为了解慢性精神分裂症中形态相似性异常的普遍性提供了见解.
- 虽然观察到连接性减少,但大多数人并没有随着时间的推移始终存在.
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