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炎症负担指数与心力衰竭风险之间的关联:来自NHANES 2003-2017年的证据

Li-Xin Yun¹, Wan-Zhong Huang², Changjing He^3,4

¹Department of Cardiology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, Guangxi, 530007, China.

BMC cardiovascular disorders

|April 24, 2025

概括

炎症负担指数 (IBI) 与心力衰竭 (HF) 的更高风险有关. 较高的IBI水平表明对HF的敏感性增加,独立于其他风险因素.

科学领域:

心脏病学心脏病学
炎症研究炎症研究
公共卫生公共卫生

背景情况:

系统性炎症是已知的心力衰竭 (HF) 进展的驱动因素.
炎症负担指数 (IBI) 是系统性炎症的综合指标.
了解IBI和HF风险之间的关系对于预防策略至关重要.

研究的目的:

研究炎症负担指数 (IBI) 与患心力衰竭 (HF) 的风险之间的关联.
确定IBI是否可以作为HF风险的独立预测指标.

主要方法:

一项横截面研究分析了来自19856名参与者的NHANES数据 (2003-2017年).
参与者根据IBI水平分为四分之一.
使用后勤回归和受限立方线分析来评估HF风险和剂量-反应关系,并对混因素进行调整.

主要成果:

与没有HF的人相比,患有HF的参与者表现出明显更高的IBI水平 (2.66 ± 0.27对1.05 ± 0.03,p < 0.001).
在IBI四分位数中,HF患病率逐渐增加 (Q1: 1.2%,Q2: 1.33%,Q3: 2.60%,Q4: 4.37%,p < 0.001).
在多变量调整后,较高的IBI四分位数 (Q3和Q4) 与高血压风险增加有关 (OR=1.06,95%CI:Q3的0.70-1.61;OR=1.46,95%CI:Q4的1.02-2.10). 证实了IBI和HF风险之间的正线性相关性.

结论:

炎症负担指数 (IBI) 的升高与心力衰竭 (HF) 的风险增加显著相关.
IBI显示出其作为一种有价值的生物标志物的潜力,用于识别超出传统风险因素的高风险HF个体.
这些发现强调了在心血管健康中管理系统性炎症的重要性.

关键词:

协会协会协会协会协会心脏衰竭是因为心脏衰竭.炎症性负担指数炎症负担指数尼汉斯 (NHANES) 是一个名人.风险风险风险风险风险

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