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心脏代谢指数与排便频率的关系:基于NHANES的横截面分析
Qianyi Ren1, Yanan Wang2, Xinhui Han1
1School of First Clinical Medicine, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
心脏代谢指数 (CMI) 通常与肠道排便频率 (BMF) 的增加相关,但在特定范围内降低了BMF. 这种肠道健康和代谢综合征的联系在年轻人和抑郁症患者中更为强烈.
科学领域:
- 代谢健康 代谢健康
- 肠道微生物组研究研究
- 心血管健康指标心血管健康指标
背景情况:
- 代谢综合征 (MetS) 与肠道健康有关.
- 心脏代谢指数 (CMI) 预测了MetS.
- 排便频率 (BMF) 反映了肠道健康,但其与CMI的关系尚不清楚.
研究的目的:
- 调查心脏代谢指数 (CMI) 和排便频率 (BMF) 之间的关联.
- 探索不同的人口和健康群体之间这种关联的潜在变化.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 数据 (2005-2010).
- 计算CMI使用甘油三,高密度胆固醇和腰部至部的比率.
- 使用回归,平滑曲线拟合和值效应分析,与子组和相互作用测试.
主要成果:
- 总共分析了9678名参与者.
- 较高的CMI四分位数与增加的BMF相关 (β=0.69).
- 观察到非线性关联:当CMI为4.97-11.75 (β=-0.78) 时,BMF下降,但在其他情况下增加.
- 关联强度因抑郁状态和年龄组而异 (P<0.05).
结论:
- CMI通常与 BMF 的增加有关,在 CMI 水平为 4.97-11.75.5 的 BMF 中显著下降.
- 在年轻人,中年人和抑郁症患者中,CMI-BMF关系更为明显.
- 突出了代谢健康指标和肠道功能之间的复杂相互作用.
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