通过向丹麦艾滋病毒感染妇女引入HPV阴道自取样来改善宫癌查参与 - - 一项试点研究
Siri Nana Halling Svensgaard1, Mette Tranberg2,3,4, Berit Andersen2,3
1Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark. SIRSTE@rm.dk.
BMC women's health
|April 24, 2025
概括
高风险HPV (hrHPV) 的阴道自取样对艾滋病毒感染妇女 (WLWH) 是可行的,但为了有效预防宫癌,需要改善后续遵守.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 子宫癌是全球重要的健康问题,因持续高风险HPV感染 (hrHPV) 感染,感染艾滋病毒 (WLWH) 的女性的风险增加了六倍.
- 尽管有效的查方法,但WLWH仍未得到充分的查,这突显了预防性护理的关键差距.
- 这项试点研究解决了需要了解查障碍和WLWH接受的需求.
研究的目的:
- 根据世卫组织的指导方针,估计未经查的WLWH的比例.
- 确定在WLWH中自取样的接受率.
- 为了评估 hrHPV DNA 流行率和这一群体的随访合规性.
主要方法:
- 一个单一中心的试点研究于2022年2月至5月在阿尔胡斯大学医院进行.
- 参与者提供了带有说明的阴道自取样套件 (Evalyn® Brush).
- 使用COBAS® 4800测定方法分析 hrHPV DNA,并使用医疗记录和丹麦病理数据库的数据进行分析.
主要成果:
- 50%的符合条件的WLWH接受了自取样,回报率为80%.
- hrHPV流行率为25%, hrHPV阳性女性的随访遵守率为40%.
- 41%的WLWH没有按照世卫组织的指导方针进行查,39%的WLWH以前从未进行过查.
结论:
- 阴道 hrHPV 自取样本对 WLWH 是可接受的,也是可行的,显示出高样本回收率.
- 低于最佳的后续遵从性需要策略来增强参与和坚持有效的宫癌预防.
- 需要进行更大规模的研究来验证这些发现,并完善WLWH的查策略.
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