凝血杆菌通过调节"肠-免疫-骨"轴来改善绝经后骨质疏松症中的炎症性骨损失
Leena Sapra1, Chaman Saini1, Pradyumna K Mishra2
1Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), An ICMR-Collaborating Centre of Excellence in Bone Health, Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Gut microbes
|April 25, 2025
概括
肠道细菌失衡 (失生症) 通过减少有益的微生物和增加有害的微生物,使骨质疏松症恶化. 益生菌补充剂通过恢复免疫平衡改善了骨健康.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 骨生物学 骨生物学 骨生物学
- 胃肠病学 胃肠病学
背景情况:
- 骨质疏松症的特点是骨密度低和骨折风险增加,由炎症性骨损失加剧.
- 绝经后骨质疏松症 (PMO) 的雌激素缺乏与调节性B细胞 (Bregs) 的减少和IL-10的产生受损有关.
- 肠道失生症,粘膜损伤和漏肠有助于炎症性疾病,包括PMO,有证据表明肠道微生物群在布雷格分化中的作用.
研究的目的:
- 研究肠道微生物群 (GM) 在雌激素缺乏PMO的发展和进展中的作用.
- 评估GM如何调节Bregs.的抗骨质疏松潜力.
- 探索针对PMO的转基因治疗的治疗潜力.
主要方法:
- 在临床前和临床骨质疏松症模型中对肠道微生物群组成进行比较分析.
- 评估骨矿物质密度,强度和微观架构.
- 在益生菌干预后评估布雷格功能,包括IL-10的产生和免疫调节能力.
主要成果:
- 失生症的特征是产生内毒素的细菌增加和短链脂肪酸生产者的减少,与PMO中炎症性骨损失的增加相关.
- 用益生菌*Bacillus coagulans*补充剂显著提高了骨矿物质密度,强度和微观架构.
- 益生菌治疗调节了Breg功能,改善了它们的抗骨质细胞生成,免疫抑制和免疫调节活动.
结论:
- 肠道失生症通过破坏肠道-免疫-骨轴,加剧雌激素缺乏PMO的骨损失.
- 恢复肠道微生物群的组成,以 * Bacillus coagulans * 补充为例,为PMO提供了一个有前途的治疗策略.
- 针对肠道微生物群,免疫平衡 (Breg-Treg-Th17轴) 和骨代谢之间的相互作用,为缓解炎症性骨损失提供了新的途径.
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