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Updated: Jul 22, 2026

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
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脊髓损伤后的创伤后生长:一个系统的审查和元民族学

Gemma Smith1,2, Andrew R Thompson1,2, Anna McCulloch3

  • 1School of Psychology, Cardiff University, Cardiff, UK.

Disability and rehabilitation
|April 25, 2025
PubMed
概括

脊髓损伤 (SCI) 后的创伤后生长 (PTG) 受社会因素的影响. 密切的关系和同行联系是身份重建和培养PTG的关键.

关键词:
脊髓损伤导致的脊髓损伤进行调整的调整.进行元合成.创伤后的成长 创伤后的成长系统性审查 系统性审查

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Spinal Cord Injury ll: Pathophysiology01:14

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Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...