血homocysteine与静脉的临床分级之间的关系
Li-Hong Wang1,2, Lei Zheng1,2, Hui Jiang3
1Department of Andrology and Sexual Medicine, The Second Hospital of Dalian Medical University, Dalian 116023, China.
Asian journal of andrology
|April 25, 2025
概括
血homocysteine (Hcy) 水平升高与静脉 (VC) 临床分级增加相关. 这一发现表明,Hcy可能是一个有价值的生物标志物,用于评估VC严重程度,并了解其内皮细胞损伤的发病因子.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 安德罗学与人类学
- 生物化学 生物化学
背景情况:
- 静脉 (VC) 是男性不孕症的一个常见原因.
- 内皮细胞损伤与VC病原发生有关.
- 血homocysteine (Hcy) 是血管内皮功能障碍的一个潜在因素.
研究的目的:
- 为了研究血类固醇 (Hcy) 水平和静脉瘤 (VC) 的临床分级之间的关联.
- 探索Hcy在VC患者内皮细胞损伤的发病过程中的作用.
主要方法:
- 一项涉及184名VC患者和120名对照者的比较研究.
- 根据VC临床分级 (I,II,III级) 患者被分为三组.
- 用单变量和多变量回归测量和分析了血Hcy水平.
主要成果:
- 与对照组相比,VC患者的中位数Hcy水平显著更高 (p=0.006).
- 在增加Hcy水平和更高的VC临床等级之间发现了积极的相关性.
- 多变量分析证实Hcy是与VC分级相关的重要因素 (p=0.013).
结论:
- 血homocysteine (Hcy) 水平与静脉 (VC) 的临床分级有显著的相关性.
- Hcy可能在导致VC的内皮细胞损伤中发挥作用.
- Hcy在评估 varicocele 的严重程度方面具有潜在的临床价值.
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