口腔状细胞癌的预后因素:系统审查和元分析
Isabel González-Ruiz1, Pablo Ramos-García2, Noor Mjouel-Boutaleb2
1Pius de Valls Hospital, Tarragona, España.
Oral diseases
|April 25, 2025
概括
口腔状细胞癌 (OSCC) 的预后因素表明,淋巴结参与,瘤大小和远程转移显著增加了死亡和复发的风险. 早期诊断对于改善OSCC患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 头部和部手术 头部和部手术
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
- 准确的预后因素对于有效的患者管理和治疗规划至关重要.
研究的目的:
- 进行全面的元分析,评估目前关于OSCC预后因素的证据.
- 综合了255项涉及63,114名患者的初级研究的数据.
主要方法:
- 在MEDLINE,Embase,Web of Science和Scopus数据库中进行系统的文献搜索,直到2024年1月.
- 使用预后研究工具的质量偏差风险评估.
- 对包括淋巴结状况,瘤入侵深度和远程转移在内的预后因素的元分析.
主要成果:
- 淋巴结参与 (cN,pN) 和囊外扩散显著与较差的整体存活率,疾病特异性存活率和无疾病存活率相关.
- 超过5mm的瘤入侵深度是增加死亡率的强有力的预测因素.
- 远程转移 (cM,pM) 成为最强大的负预后因素,尽管初级研究数据有限.
结论:
- 受影响的部节点,较大的瘤大小和远程转移的存在是OSCC增加死亡率和复发风险的关键指标.
- 迫切需要实施增强早期OSCC诊断的策略,以减轻诊断延迟和提高患者存活率.
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