晚期癌症的营养干预:范围审查
Aynur Aktas1, Shirley Thomas2, Michelle Barrett3
1Department of Supportive Oncology, Atrium Health Levine Cancer Institute, Charlotte, NC, USA.
The American journal of hospice & palliative care
|April 25, 2025
概括
在晚期癌症中进行营养干预的证据有限. 虽然饮食建议和补充剂可能有助于耐受性和营养状况,但整体生存益处是不一致的,需要个性化策略.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 证据综合 证据综合
背景情况:
- 有限的证据支持对晚期癌症患者的营养建议.
- 由于异质性,晚期癌症的营养干预缺乏关于有效性的共识.
- 需要总结当前的饮食和营养方法及其证据基础.
研究的目的:
- 绘制和总结当前关于晚期癌症营养干预措施的证据基础.
主要方法:
- 在五个数据库 (CINAHL Ultimate,Embase,Medline,SCOPUS,Web of Science) 进行系统搜索,截至2023年10月20日.
- 包括对晚期癌症成年人营养干预的研究,不包括肠道/肠道营养.
- 由于研究异质性,叙述数据的合成.
主要成果:
- 35项研究符合纳入标准,其中25项 (69%) 是随机对照试验.
- 干预措施包括营养药,性饮食,营养建议,口服补充剂等.
- 虽然报告了一些积极的结果,但证据不足以提出最终的建议.
结论:
- 范围审查发现,在晚期癌症中,各种营养干预措施的证据有限.
- 饮食建议和口服营养补充剂可能会改善营养状况和治疗耐受性,但生存影响不一致.
- 由于结果的变化,需要个性化的营养策略.
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