检查睡眠呼吸暂停和总海马体积在认知障碍中的关联
Matthew Settimi1,2,3, Dennis Tchoudnovski1,2,4, Ivan Ntale1,2,4
1Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Wellness Way, Toronto, Ontario, Canada.
概括
阻塞性睡眠呼吸暂停 (OSA) 与神经退行性或血管性认知障碍患者的海马体积较小有关. 缺氧负担,而不仅仅是呼吸暂停的严重程度,与这种大脑体积损失相关,这表明这些人的易感性增加.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 神经成像是一种神经成像.
背景情况:
- 由于人口老龄化,全球痴呆症的患病率正在增加.
- 阻塞性睡眠呼吸暂停 (OSA) 对脑血管健康构成风险.
- 调查OSA和认知衰退之间的联系至关重要.
研究的目的:
- 测试OSA标志物与神经退行性,血管性或混合性 (NVM) 认知障碍患者的海马体积减少相关的假设.
- 探索睡眠障碍呼吸与认知障碍患者大脑结构之间的关系.
主要方法:
- 对166名接受睡眠研究 (多睡眠学或家庭睡眠呼吸暂停测试) 和脑MRI的患者进行了回顾性分析.
- 患者被分为NVM病因或主观认知投诉组.
- 用多个线性回归模型来评估睡眠变量与海马体积之间的关联.
主要成果:
- 在NVM组中,OSA存在,氧和率低于90% (T90%) 的时间和平均SpO2显著与海马体积减少有关.
- 在主观认知投诉组中,这些OSA标志物和海马体积之间没有发现显著的关联.
- 低氧负担,以T90%和平均SpO2表示,与海马体积损失的联系比呼吸暂停-呼吸暂停指数 (AHI) 更强烈.
结论:
- 患有NVM认知障碍的个体表现出潜在的神经退行过程,这可能会增加他们对OSA不良影响的敏感性.
- 由OSA引起的缺氧负担似乎是与此种人群中海马体积减少相关的关键因素.
- 这些发现强调了在患有神经退行性和血管起源的认知障碍的患者中解决OSA的重要性.
关键词:
在这里,AHI AHI.呼吸暂停 睡眠暂停指数在HSAT上,你会得到HSAT.在OSA中使用OSA.脑部成像 脑部成像在海马体内,海马体的体积.在家做睡眠呼吸暂停测试.神经退行性疾病的神经退行性疾病神经成像是一种神经成像.阻塞性睡眠呼吸暂停症是什么聚类人体图像 (polysomnography) 是一种多人体图像.血管痴呆症是一种精神病.更多相关视频
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