吸入器使用中的诺塞博效应:患者的信念和治疗坚持
Eduardo Garcia-Pachon1, María J Soler-Sempere1, Sandra Ruiz-Alcaraz1
1Hospital General Universitario de Elche, Elche, Alicante, and Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Spain.
诺塞博效应,即患者出现非药物引起的症状,会影响吸入器的使用. 16%的患者报告了nocebo症状,与担忧和较低的坚持有关.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 精神病体医学是一种精神病体医学.
- 患者坚持的研究研究.
背景情况:
- 诺塞博效应涉及与药理学无关的与治疗相关的非特异性症状.
- 这可能会对治疗的坚持产生负面影响,并增加医疗保健利用率.
研究的目的:
- 确定使用吸入器的患者中nocebo效应的患病率和性质.
- 在吸入治疗期间识别与nocebo效应相关的因素.
主要方法:
- 对患者进行了采访,以了解吸入器的感知不良影响.
- 问卷评估了药物信仰,对药物的敏感性和使用验证的尺度的坚持.
- 通过吸入器粘附测试和处方补充率客观地测量了粘附性.
主要成果:
- 在134名患者中,21人 (16%) 经历了因吸入器而产生的与nocebo相关的症状.
- 报告有nocebo症状的患者对吸入器使用的担忧增加,对药物的感知敏感性更高.
- 在经历了nocebo效应的患者中观察到较低的治疗坚持.
结论:
- 使用吸入器的大量患者将与药物无关的负面症状归因于他们的药物.
- 诸如负面的药物信念和较低的坚持等因素与吸入器使用者的nocebo效应有关.
- 解决患者的信念和担忧对于改善吸入疗法的坚持至关重要.
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