活跃结核病患者中阳性抗核抗体的频率及其与抗结核疗法的变化
Naznin Naher1, Hasan Imam1, Sunil Kumar Biswas1
1Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, BGD.
Cureus
|April 25, 2025
概括
抗核抗体 (ANA) 可能存在于活跃结核病 (TB) 患者中. 大多数ANA阳性结核病患者在六个月的治疗后清除了这些抗体,这表明ANA阳性在结核病中通常是暂时的.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- 结核病 (TB) 是一种常见的传染病,可以影响免疫功能并诱导抗核抗体 (ANA) 等自身抗体.
- 在结核病和自身免疫性疾病 (例如SLE) 中都观察到ANA阳性,由于重叠的症状,可能会使诊断复杂化.
- 在成功治疗结核病后,ANA阳性的解决仍然在很大程度上没有特征.
研究的目的:
- 为了确定在患有活跃结核病的患者中ANA的流行率.
- 为了研究在开始抗结核治疗后,ANA状态的变化.
主要方法:
- 一项前性观察性研究,涉及150名新诊断出活跃结核病的成年患者,并没有先前的自身免疫性疾病史.
- 在基线时进行ANA测试,并在开始抗结核病治疗后的3个月和6个月重复进行.
- 统计分析包括千平方,t测试和曼-惠特尼U测试用于定性数据.
主要成果:
- 在150名活跃结核病患者中,有13名 (8.7%) 在基线时为ANA阳性.
- 在肺结核 (11.3%) 和肺外结核 (7.2%) 中观察到ANA阳性.
- 粗的斑点图案是最常见的ANA发现 (69.23%).
- 经过六个月的抗结核治疗,92.3% (12/13) 的最初ANA阳性患者变得ANA阴性.
结论:
- 在患有活性肺结核和肺外结核的患者中可以检测到抗核抗体.
- 在活性结核病中,ANA阳性似乎在成功治疗后在很大程度上是可逆的.
- 在ANA和活跃结核病本身之间没有发现显著的关联,这表明过渡性阳性.
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