维生素D补充剂对血压的影响:系统性审查
Hannah John1, Shrey Gondalia2, Jitender Sharma3
1Medical Writing, Index Research International, Vadodara, IND.
Cureus
|April 25, 2025
概括
补充维生素D可能会降低血压,更高剂量显示出更大程度的减轻心压和心压血压. 需要进一步的研究来确定最佳的维生素D剂量用于高血压管理.
科学领域:
- 心血管健康 心血管健康
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 高血压是心血管疾病和死亡的重要危险因素.
- 建议维生素D在血压调节中的作用是通过renin-angiotensin-aldosterone系统,内皮功能和炎症.
- 关于维生素D和血压的现有干预研究结果是不一致的.
研究的目的:
- 系统地审查维生素D补充剂对心压和腹压血压的影响.
- 为了评估这些影响在不同的人口.
- 综合来自随机对照试验和队列研究的证据.
主要方法:
- 在PubMed,Cochrane Central和ScienceDirect进行了全面的文献搜索.
- 12项研究 (RCT和队列研究) 符合纳入标准.
- 数据提取和偏差风险评估由两位独立审查员进行.
主要成果:
- 维生素D补充剂显示可能降低血压.
- 观察到的最高降低是-50,000 IU/周的静缩-28.44 mmHg和静缩-7.38 mmHg.
- 其他研究报告较小的减少 (-0.5至-4.5毫米缩,-1至-5毫米缩),受剂量和持续时间的影响.
结论:
- 维生素D补充剂可能有助于降低血压,特别是在更短的时间内服用更高剂量.
- 在研究中存在显著的异质性.
- 需要进一步的研究来确定对高血压患者的最佳维生素D剂量策略.
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