在局部侵袭性皮肤状细胞癌中恶性发作性伤口:一个病例系列
Tarek Zieneldien1, Holly Lam2, Sophia Ma1
1Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
Cureus
|April 25, 2025
概括
管理高风险状细胞癌 (SCC) 与二次感染是复杂的. 这项研究详细介绍了两名免疫功能低下的患者,患有侵袭性皮肤SCC (cSCC) 和多药耐药Pseudomonas aeruginosa感染,突出了治疗挑战.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 皮肤病学 皮肤病学
背景情况:
- 高风险状细胞癌 (SCC) 的管理具有挑战性,二次感染报告不足.
- 患有皮肤癌的免疫功能低下患者面临感染易感性增加和疾病负担增加.
- 在晚期癌症中,恶性功能性伤口 (MFW) 可能被误诊,使治疗复杂化.
研究的目的:
- 在两个患有局部侵袭性SCCs,MFWs和Pseudomonas aeruginosa感染的患者中,描述疾病进展,治疗疗效和危险因素.
- 要突出皮肤SCC (cSCC) 在免疫受损个体的管理的复杂性.
主要方法:
- 对两名免疫功能低下患者 (艾滋病毒,肺移植接受者) 的病例报告分析.
- 详细描述瘤入侵,二次感染和治疗反应.
- 专注于并发症,包括多抗药性Pseudomonas aeruginosa.
主要成果:
- 两位患者都呈现出侵略性的cSCC,广泛的瘤入侵,以及慢性,多药耐药的Pseudomonas aeruginosa感染.
- 管理需要平衡瘤治疗,息治疗和传染病控制.
- 病例说明了cSCC在免疫受损宿主中的攻击性.
结论:
- 在免疫功能低下的患者中,侵略性的cSCC会带来重大管理挑战.
- 二次感染,特别是多药耐药细菌,如Pseudomonas aeruginosa,使治疗复杂化.
- 在这些复杂的病例中,多学科的方法对于管理瘤和感染方面至关重要.
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