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Updated: Jul 21, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

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由急性髓性白血病衍生的细胞外囊泡诱导的DNA甲基化变化,在正常的造血干细胞前代细胞中负责炎症程序

Daniela Lamorte1, Giovanni Calice1, Stefania Trino1

  • 1Laboratory of Preclinical and Translational Research, IRCCS Centro di Riferimento Oncologico della Basilicata (CROB), Rionero in Vulture (PZ), Italy.

Frontiers in immunology
|April 25, 2025
PubMed
概括

急性髓性白血病 (AML) 细胞释放细胞外囊泡 (EVs),改变健康的造血干细胞 (HSPCs) 中的DNA甲基化. 这种表观基因组重编程会影响参与炎症和血液形成的基因,可能导致类似白血病的变化.

关键词:
通过DNA甲基化.急性骨髓性白血病 (AML) 是一种急性骨髓性白血病.不同表达的基因.细胞外囊泡中的细胞外囊泡.血液形成 血液形成造血干细胞和原始细胞.这是一种炎症炎症炎症炎症.这就是白血病的产生.

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