在非住院患者中,默认模式网络的功能连接在COVID后的认知投诉
Derek Madden1, Tressie M Stephens2, Jim Scott3
1Stephenson School of Biomedical Engineering, Gallogly College of Engineering, The University of Oklahoma, Norman, OK, United States.
Frontiers in neuroscience
|April 25, 2025
概括
轻度COVID-19后的认知缺陷与大脑的默认模式网络 (DMN) 有关. 较高的DMN连接度与从病毒中恢复过来的个体中更好的神经认知表现相关.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 传染性疾病 传染性疾病
背景情况:
- 在感染SARS-CoV-2 (COVID-19) 的患者中,经常观察到神经功能障碍,包括认知功能障碍.
- 即使是轻微的COVID-19病例也可能导致多达20%的患者出现记忆障碍等认知问题.
研究的目的:
- 为了调查神经成像相关的认知投诉的成年人轻度,非住院COVID-19.
- 描述默认模式网络 (DMN) 的功能连接,与COVID-19后的神经认知表现相关.
主要方法:
- 招募了COVID后认知投诉和轻度疾病的成年人.
- 进行了正式的神经心理测试和功能性MRI (fMRI).
- 分析了DMN中的功能连接,DMN以其在记忆和注意力中的作用而闻名.
主要成果:
- 患有轻度COVID-19的参与者表现出认知表现与认知完整的个人相比.
- 在DMN中保留了功能连接.
- 在DMN连接和认知得分 (r=0.51,p=0.02) 之间发现了正相关性,高表现者表现出更大的DMN连接.
结论:
- 在COVID-19后轻度认知缺陷的个体中提供了DMN功能连接的神经图像证据.
- 研究结果表明预期的功能性大脑趋势,并提供关于DMN功能和COVID-19后神经认知恢复的见解.
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