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休时间体育活动模式与美国成年人表型年龄加速之间的剂量反应关系:横截面分析
Dongzhe Wu1, Peng Huang2, Xue Geng3
1Exercise Biological Center, China Institute of Sport Science, Beijing, China.
Journal of exercise science and fitness
|April 25, 2025
概括
定期的休时间体育活动 (LTPA) 显著减缓生物衰老,但过量可能会加速它. 适度的LTPA对健康的衰老是最有益的,强调个性化的活动建议.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 全球人口老龄化需要推迟和促进健康老龄化的战略.
- 现型衰老加速 (PhenoAgeAccel) 作为生物衰老速度的关键生物标志物.
- 了解生活方式因素,如身体活动对PhenoAgeAccel的影响至关重要.
研究的目的:
- 调查各种休时间体育活动 (LTPA) 模式与PhenoAgeAccel之间的关联.
- 分析LTPA和PhenoAgeAccel之间的剂量反应关系.
- 确定这种关系中的潜在非线性效应和值.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) (1999-2018) 中14868名成年人的数据.
- 采用多变量线性回归和限制立方支线方法来建模LTPA和PhenoAgeAccel.
- 应用分段概率测试和分层分析来检查非线性和子组效应.
主要成果:
- 与没有LTPA相比,不活跃和定期的LTPA模式与显著较低的PhenoAgeAccel相关.
- 观察到非线性值效应:560分钟/周以下的LTPA与降低的PhenoAgeAccel相关,而超过这个值,它与增加的PhenoAgeAccel相关.
- "周末战士"LTPA模式对PhenoAgeAccel没有显著影响.
结论:
- 定期,中度的LTPA与降低的PhenoAgeAccel有关,这表明对生物衰老有有益影响.
- 存在非线性剂量反应关系,在一定每周活动值以下观察到的最佳益处.
- 这些发现支持个性化体育活动指南,以促进健康的衰老,并为公共卫生干预提供信息.
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