在评估ETDD时ETDQ-7评分的有用性
Niels Højvang Holm1, Therese Ovesen2
1Department of Otorhinolaryngology, Head and Neck Surgery, Gødstrup Hospital, Herning, Denmark.
概括
尤斯塔基管功能障碍问卷-7 (ETDQ-7) 有效地诊断尤斯塔基管功能障碍 (ETD) 并评估治疗结果. 在插入通风管后,ETDQ-7得分显著改善,表明症状缓解.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 医学诊断 医学诊断 医学诊断
背景情况:
- 欧斯塔基管功能障碍问卷-7 (ETDQ-7) 已被验证用于诊断欧斯塔基管功能障碍 (ETD).
- 对于ETDQ-7.7,已提出≥3.5的最小临床重要差异 (MCID).
- 本研究评估ETDQ-7用于ETD诊断及其与中鼻结局测试22 (SNOT-22) 的相关性.
研究的目的:
- 评估ETDQ-7在成人ETD患者的诊断效用.
- 用ETDQ-7.来评估通风管插入 (VTi) 在改善ETD症状方面的有效性.
- 在ETD患者中探索ETDQ-7和SNOT-22得分之间的相关性.
主要方法:
- 在75名成年患者中,ETD诊断是基于耳部症状和负中耳压的客观迹象.
- 在受影响的耳朵上进行了通风管插入 (VTi).
- 在VTi之前和VTi后一个月收集ETDQ-7和SNOT-22得分,并与75名健康对照进行比较.
主要成果:
- 平均ETDQ-7得分在VTi后显著下降,从31.9降至15.8 (p < 0.0001),在所有接受治疗的耳朵中实现了MCID.
- 对于ETDQ-7的切线分数>14.5显示出100%的灵敏度和94.2%的特异性来诊断ETD.
- 在基线ETDQ-7和SNOT-22之间发现了显著的相关性 (p=0.012),ETD患者报告了更高的鼻腔,耳腔和睡眠症状得分.
结论:
- ETDQ-7是诊断ETD和评估VTi的影响的非常有效的工具.
- ETDQ-7得分表明VTi后的症状缓解,但并不意味着治疗潜在的病理生理学.
- 未来的研究应该考虑耳朵特异性的ETDQ-7评分,更高的MCID值和生活质量指标.
相关概念视频
01:18Effects of EDTA on End-Point Detection Methods
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Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
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01:23EDTA: Indirect and Alkalimetric Titration
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Unlike direct titration, back-titration, and displacement titration, indirect titration is an EDTA titration method for quantifying anions. In the indirect titration method, anions are precipitated as their insoluble salts with excess metal ions. The filtrate containing the excess metal ions is directly titrated with standard EDTA until the endpoint is achieved. Another approach involves extracting the metal ion and back-titrating with standard EDTA to obtain the endpoint. In this way, the...
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01:30EDTA: Direct, Back-, and Displacement Titration
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The EDTA titration types for metal ion analysis include direct titration, back-titration, and replacement titration.
Direct titration involves buffering the metal ion solution to the desired pH and directly titrating with standard EDTA until the endpoint. The optimum pH ensures a large conditional formation constant of metal−EDTA and visibility of the free indicator color in the solution. In addition, auxiliary complexing reagents are used to prevent the precipitation of metal hydroxides...
Direct titration involves buffering the metal ion solution to the desired pH and directly titrating with standard EDTA until the endpoint. The optimum pH ensures a large conditional formation constant of metal−EDTA and visibility of the free indicator color in the solution. In addition, auxiliary complexing reagents are used to prevent the precipitation of metal hydroxides...
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