癌症免疫疗法和心脏健康的关键挑战
Aftab Alam1, Sushma Devi2, Sana Hashmi3
1Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
Current cardiology reviews
|April 25, 2025
概括
使用免疫检查点抑制剂 (ICI) 的癌症免疫疗法可能会导致心脏问题. 本综述建议使用生物标志物,成像和人工智能进行风险评估,以提高这些重要癌症治疗的安全性和有效性.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 用免疫检查点抑制剂 (ICI) 进行的癌症免疫疗法彻底改变了癌症治疗.
- 与免疫相关的不良事件 (irAEs),特别是心脏毒性,经常限制ICI的疗效.
- 迫切需要强大的模型来评估与ICI相关的心脏风险.
研究的目的:
- 阐明ICI诱导心脏毒性的机制.
- 为心脏不良事件提出风险评估策略.
- 探索用于定制癌症免疫治疗方案的预测工具.
主要方法:
- 对ICI相关心脏毒性现有文献的综述.
- 生物标志物,非侵入性成像和个体患者数据的整合用于风险评估.
- 讨论人工智能 (AI) 和机器学习 (ML) 用于风险预测.
主要成果:
- 生物标志物对于早期检测和预防心脏副作用至关重要.
- 结合生物标志物,成像和患者数据的多模式方法可以提高风险评估.
- 人工智能/ML可以合成复杂的数据以识别模式和风险因素.
结论:
- 开发健全的风险评估模型对于提高癌症免疫疗法的安全性和有效性至关重要.
- 需要预测工具来个性化治疗和减轻心脏风险.
- 整合AI/ML为改善ICI安全性和患者结果提供了强大的能力.
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