人工智能驱动的药物开发和药物输送系统创新
Ting Zhu1,2, Bing Liu1,2, Ning Chen1,2
1Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin, China.
Current topics in medicinal chemistry
|April 25, 2025
概括
人工智能 (AI) 正通过优化药物设计和增强药物输送系统 (DDS) 来彻底改变药物开发. 这项技术通过先进的预测和智能制造来提高效率,安全性和个性化医疗.
科学领域:
- 制药科学 制药科学
- 人工智能的人工智能
- 药物输送系统 药物输送系统
背景情况:
- 人工智能 (AI) 技术的快速进步正在越来越多地影响制药研究和开发.
- 人工智能在优化药物设计,提高研发效率和改善产品安全概况方面具有重大潜力.
- 人工智能的整合支持通过先进的数据分析和预测建模实现个性化医疗.
研究的目的:
- 系统地检查AI在制药配方中的基本应用和原则.
- 评估AI在关键领域的作用,包括药物开发,制造,质量控制和ADME/T预测.
- 探索AI整合在制药开发,监管和决策中的机遇和挑战.
主要方法:
- 在制药配方和药物输送系统 (DDS) 中对人工智能应用的审查.
- 机器学习 (ML) 模型的分析,以优化DDS,纳米载体设计和个性化药物释放.
- 检查AI在智能制造技术 (如3D打印和连续制造) 中的作用.
主要成果:
- 人工智能提高了对关键药物属性的预测准确度,例如溶解性,稳定性和生物可用性.
- 人工智能优化了新的DDS,实现了个性化药物释放控制和先进的纳米载体设计.
- 人工智能集成对于推进智能制造工艺和改善药品质量控制至关重要.
结论:
- 人工智能技术具有巨大的潜力,可以彻底改变制药配方和药物输送系统 (DDS).
- 人工智能整合有望显著提高药物开发效率,安全性和个性化医疗的实施.
- 解决人工智能的机遇和挑战对于改变制药开发和监管实践至关重要.
相关概念视频
Issues And Trends In Healthcare Delivery System
5.5K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.5K
Structure-Activity Relationships and Drug Design
437
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
437
Drug Discovery: Overview
7.1K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.1K
Drug Administration and Therapy Phases: Overview
385
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
385
Biopharmaceutics and Pharmacokinetics: Overview
1.7K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
1.7K
Drug Delivery: Miscellaneous Routes
272
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
272


