在糖尿病中改善ASCVD查:关注评分模型和检测技术
Răzvan-Liviu Zanfirescu1,2, Larisa Anghel1,2, Bogdan-Sorin Tudurachi1,2
1Cardiovascular Diseases Institute "Prof. Dr. George I. M. Georgescu" Iaşi, România.
概括
2型糖尿病 (T2DM) 显著增加了动脉样硬化心血管疾病 (ASCVD) 的风险. 加强查和新疗法对于糖尿病患者ASCVD的早期检测和管理至关重要.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 动脉样性心血管疾病 (ASCVD) 是2型糖尿病 (T2DM) 患者的主要死亡原因.
- 糖尿病通过胰岛素耐药性,高血糖,失脂症,炎症和氧化应激加速动脉样硬化.
- 现有的风险模型不足以解决T2DM的残留心血管风险.
研究的目的:
- 审查T2DM和ASCVD之间的病理生理联系.
- 突出在糖尿病人群中加强查方案的需要.
- 讨论先进的风险评估工具和新兴的治疗策略.
主要方法:
- 对T2DM,动脉样硬化和心血管风险的当前文献的综述.
- 检查连接糖尿病和ASCVD的病理生理机制.
- 评估先进的查技术和新的治疗目标.
主要成果:
- 通过多种代谢和炎症途径,T2DM显著增加ASCVD风险.
- 非侵入性成像 (例如,冠状动脉评分,CCTA) 和生物标志物 (例如,多基因风险评分) 显示出早期检测的希望.
- 目前正在研究针对炎症和胰岛素抵抗的治疗策略.
结论:
- 对T2DM患者来说,增强的查协议和高级风险分层是必不可少的.
- 需要新的诊断工具和治疗方法来降低ASCVD发病率和死亡率.
- 在T2DM中解决残留心血管风险需要采用多方面的方法.
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