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Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...

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基于向上转换的光动力疗法用于牛皮皮炎.

Zhenjia Lin¹, Xiaoyu Ji², Jinyu Liu¹

¹Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.

ACS applied bio materials

|April 25, 2025

概括

上转化纳米粒子 (UCNPs) 提供了一种新的方法,用于治疗牛皮的光动力疗法 (PDT). 这项研究表明,UCNP介导的PDT通过向巨细胞和抑制皮肤细胞过度增殖,有效治疗牛皮皮炎.

关键词:

巨细胞是一个巨细胞.光动力学疗法是一种光动力学疗法.牛皮是一种牛皮.有活性氧物种的反应性氧物种.上升转换是一种上升转换.

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科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
皮肤病学皮肤病学

背景情况:

牛皮影响全球2-3%,导致红血,和并发症,显著影响生活质量.
目前的牛皮治疗方法,如生物制剂,传统药物和光疗,都有其局限性,包括成本,疗效和副作用.
光动力学疗法 (PDT) 是有前途的,但由于光敏剂的光透性差,其受限.

研究的目的:

开发和评估升级转换纳米粒子 (UCNCNPs) 用于增强光动力学疗法 (PDT) 在牛皮治疗中.
为了克服传统的皮病PDT中有限的光透的挑战.
研究使用近红外 (NIR) 光治疗牛皮皮炎的UCNP介导PDT的疗效.

主要方法:

合成的UCNP涂有多孔的二氧化外,并用光敏感剂 (ZnPc) 封装,形成UCNP-ZnPc.
局部应用UCNPs-ZnPc到牛皮的小鼠模型.
使用980nm NIR光激活UCNPs-ZnPc,以诱导反应性氧物种的产生.

主要成果:

UCNPs-ZnPc被牛皮病小鼠皮肤中的巨细胞有效地吸收.
对UCNPs-ZnPc的NIR光激活导致巨细胞活力降低.
治疗抑制了牛皮性皮肤细胞的过度增殖,有效治疗皮肤炎.
在临床前牛皮病模型中证明了UCNP介导PDT的成功应用.

结论:

以UCNPs为媒介的PDT提供了一种有希望的策略,以克服皮病治疗中的光透限制.
这种方法有效地向巨细胞,并抑制牛皮的皮肤细胞增殖.
UCNPs-ZnPc代表了一种创新的治疗途径,用于治疗牛皮,有可能改善临床结果.