一个共同的模型,用于 (无) 边界的纵向标记,竞争的风险,和使用患者登记数据的反复事件的患者登记数据
Pedro Miranda Afonso1,2, Dimitris Rizopoulos1,2, Anushka K Palipana3,4
1Department of Biostatistics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Statistics in medicine
|April 25, 2025
概括
这项研究引入了一种新的贝叶斯联合模型来分析复杂的生存数据,包括反复和竞争事件以及受界生物标志物. 该模型为疾病进展和生物标志物协会提供了更精确的见解.
科学领域:
- 生物统计学 生物统计学
- 纵向数据分析 纵向数据分析
- 生存分析的分析.
背景情况:
- 纵向和生存数据的联合模型很受欢迎,但与复杂的数据结构 (如反复和竞争事件) 斗争.
- 现有的模型经常假设生物标记物的高斯分布,这不适合边界标记物,导致结果偏差.
- 在单个模型中处理多个边界纵向标记以及反复和竞争事件是具有挑战性的.
研究的目的:
- 提出一个新的贝叶斯共享参数联合模型.
- 为了同时容纳多个 (可能有边界的) 纵向标记,反复发生的事件和相互竞争的风险.
- 改进复杂的生存数据和生物标志物协会的分析.
主要方法:
- 开发了一个贝叶斯共享参数联合模型.
- 对于边界的纵向标记,使用了β分布.
- 嵌入的反复事件流程和竞争风险.
- 模拟了各种关联形式,不连续的风险间隔和间隙/日历时间表.
主要成果:
- 一项模拟研究表明,与更简单的关节模型相比,性能优越.
- 该模型应用于美国囊性纤维化基金会患者登记.
- 肺功能,BMI和肺部恶化之间的量化关联,占死亡和移植的竞争风险.
结论:
- 拟议的模型有效地处理复杂的生存数据,具有多个边界标记和竞争风险.
- 它提供了对疾病进展的更精确的见解,正如Cystic Fibrosis Foundation患者登记册分析所显示的那样.
- 在 R 包 JMbayes2 中的高效实现有助于复杂的分析.
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