相关实验视频

Updated: May 10, 2025

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

一个新的发现:Corydalis yanhusuo引起异常肝毒性及其潜在机制

Longxin Guo^1,2, Li Lin², Jun Ling²

¹School of Pharmacy, Dali University, Dali, China.

Biomedical chromatography : BMC

|April 25, 2025

概括

科里达利斯 (Corydalis) yanhusuo (YHS) 通过激活炎症通路,可以引起异常药物诱导的肝损伤 (IDILI). 这项研究确定了与YHS肝毒性相关的关键基因和代谢物变化,有助于更安全的临床使用.

科学领域:

药理学药理学是指药理学的学科.
毒理学毒理学毒理学
传统中国医药传统中国医药

背景情况:

(Corydalis yanhusuo,简称YHS) 是一种用于缓解疼痛的传统中医药.
越来越多的报道将YHS与肝损伤联系起来,但机制仍然不清楚.
了解YHS的肝毒性对于安全的临床应用至关重要.

研究的目的:

研究由YHS.引起的特异性药物诱导性肝损伤 (IDILI) 的机制.
为了确定涉及YHS诱导的肝毒性分子通路和代谢物.
为安全和合理使用YHS提供见解.

主要方法:

对炎症激活模型进行了转录学和代谢学分析.
分析了基因表达和代谢物概况,以确定差异变化.
测量了关键炎症性细胞因子 (TNF-α,IL-1β,IL-6) 的水平.

主要成果:

在炎症激活模型中,YHS诱导IDILI.
确定了459个不同的基因和25个不同的代谢物.
丰富分析显示,TNF,NF-κB,甘氨酸脂,脂和酸代谢途径的显著参与.
YHS显著增加了TNF-α,IL-1β和IL-6水平.

结论:

由YHS引起的肝毒性与TNF和NF-κB信号通路的激活有关.
葡萄糖脂,脂和酸代谢与YHS肝毒性有关.
这些发现为预防和管理与YHS相关的肝脏风险提供了参考.

关键词:

科里达利斯 (Corydalis) 在这里生活.肝毒性肝毒性肝毒性奇特的药物诱导性肝损伤.代谢生物组的代谢生物组翻译学翻译学翻译学翻译学

更多相关视频

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

相关概念视频

Enzyme Inhibition

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.