上腺素:在过敏患者中快速降低药物敏感性的生命线
J Gil-Serrano1,2,3, P Galvan-Blasco1,2,3, J Pereira-Gonzalez1,2,3
1Allergy Department. University Hospital Vall d'Hebron, Barcelona, Spain.
Journal of investigational allergology & clinical immunology
|April 25, 2025
概括
上腺素输注 (AI) 可以安全地管理化学疗法剂和单克隆抗体的快速药物脱敏 (RDD) 期间的严重药物过敏反应. 这种辅助疗法在高危患者中减轻了反应,通常是轻微的副作用.
科学领域:
- 临床免疫学临床免疫学
- 药理学 药理学是指药理学的学科.
- 过敏和免疫学 过敏和免疫学
背景情况:
- 化疗剂 (CMT) 和单克隆抗体 (mAbs) 经常导致药物过敏.
- 快速药物脱敏 (RDD) 是这些过敏的常见管理策略.
- 严重的突破反应 (BTR) 可以复杂化RDD,可能导致治疗失败.
研究的目的:
- 评估上腺素输注 (AI) 作为RDD期间辅助的疗效和安全性.
- 评估AI在标准RDD协议期间管理严重药物过敏反应 (DHRs) 的作用.
主要方法:
- 对接受CMT或mAbsRDD的患者进行了回顾性观察研究 (2015年1月 - 2024年6月).
- 纳入标准:由于严重的DHR或RDD失败而需要AI的患者.
- 评估并发症,上腺素剂量和不良事件 (AE).
主要成果:
- 在151个RDD程序中,在42名患者中使用了上腺素输注 (AI).
- 最常见的毒剂:白金盐 (58%),mAbs (26%),税 (14%).
- 常见的初始BTR是中度/严重的过敏反应 (65%);AI诱导的不良事件包括 (14%) 和心跳动 (7%),这些都是短暂的.
结论:
- 上腺素输注 (AI) 是高风险RDD程序的有价值和安全的辅助.
- 人工智能有效地减轻了严重的药物过敏反应 (DHRs).
- 在RDD期间与AI相关的不良事件通常是轻微的.
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