手术与化学辐射治疗对口腔状细胞癌的治疗:一个多维横截面研究
Giuseppe Riva1, Dario Gamba1, Simone Moglio1
1Division of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, Via Genova 3, 10126 Turin, Italy.
Diseases (Basel, Switzerland)
|April 25, 2025
概括
对于口腔状细胞癌 (OPSCC),手术和化学辐射疗法 (CRT) 对生活质量,言语,吞,睡眠和营养有类似的长期影响.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 辐射瘤学 辐射瘤学
背景情况:
- 口腔状细胞癌 (OPSCC) 的管理需要多学科的投入.
- 手术和化学辐射疗法 (CRT) 是OPSCC的主要治疗方式.
- 评估患者的长期结果对于治疗优化至关重要.
研究的目的:
- 为了比较通过手术治疗的OPSCC患者的生活质量,言语,吞,睡眠,心理困扰和营养状况与CRT.
- 为治疗后的功能结果和幸福感提供全面的分析.
- 提供有关OPSCC治疗策略的临床决策信息.
主要方法:
- 一项涉及30名OPSCC患者的横截面研究,随访时间超过12个月.
- 患者被分为两组:手术±辅助治疗 (15) 和独家CRT (15).
- 经过验证的问卷评估了生活质量,言语,吞,睡眠,心理困扰,疼痛和营养状况.
主要成果:
- 在所有评估参数中,在手术和CRT组之间没有观察到统计学上显著的差异.
- 两组患者均报告生活质量普遍良好.
- 在手术组的60%和CRT组的40%观察到睡眠质量差.
- 在这两组中,营养不良的风险都很高,特别是在CRT组 (93.3%的低/中等风险).
结论:
- 手术和独家CRT显示OPSCC患者的长期结果相似.
- 包括生活质量,言语,吞,睡眠和营养状况在内的功能结果在两种治疗方式之间是相似的.
- 这些发现支持这两种治疗方法在长期患者福祉方面的等价性.
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