艰难菌感染的全球负担,2016-2024年:系统性审查和元分析
Rachel A A Akorful1, Alex Odoom1, Aaron Awere-Duodu1
1Department of Medical Microbiology, University of Ghana Medical School, Korle Bu, Accra P.O. Box KB 4236, Ghana.
Infectious disease reports
|April 25, 2025
概括
困难菌感染 (CDI) 不成比例地影响医疗保健机构,长期护理机构和儿科患者,特别是在北美. 针对性预防策略对于这些高负担地区至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 困难菌感染 (CDI) 是一个重要的全球医疗保健相关感染.
- 了解CDI的地理和人口变化对于有效的预防至关重要.
研究的目的:
- 为了确定CDI的全球流行病学.
- 确定不同环境和地理区域的疾病负担.
主要方法:
- 在PubMed,Scopus和Web of Science (2016-2024) 的系统文献搜索.
- 使用随机效应模型进行元分析,以汇集发病率和结果估计.
- 包括来自24个国家和不同地区的59项研究.
主要成果:
- 在入院医疗机构 (5.31例/1000人) 和长期护理机构 (44.24例/10,000个患者日) 观察到的CDI发病率最高.
- 儿童群体的风险较高 (4.52例/1000次入院),与成人 (2.13例/1000次入院) 相比.
- 社区获得的CDI的复发率最高 (16.22%),30天和不确定持续时间的死亡率分别为8.32%和16.05%.
结论:
- 医疗保健设施,长期护理,儿科人口和北美受CDI的影响不成比例.
- 调查结果指导了抗微生物药物管理,感染控制和监测工作的优先领域.
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