双重病原体:疾病,发生率,醇耐药性和生物膜
Dongmei Li1, Kincer Amburgey-Crovetti1, Emilie Applebach1
1Department of Microbiology and Immunology, School of Medicine, Georgetown University, 3900 Reservoir Rd., Washington, DC 20057, USA.
Journal of fungi (Basel, Switzerland)
|April 25, 2025
概括
由于抗真菌耐药性,类物种是高优先级的病原体. 本综述探讨了它们对人类健康和农业的影响,重点关注醇抗性机制.
科学领域:
- 医学真菌学 医学真菌学
- 植物病理学 植物病理学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 类物种对抗真菌药物的耐药性越来越强,对人类健康和全球粮食安全构成重大威胁.
- 这些真菌是双重病原体,影响人类和作物,导致临床治疗和农业管理的挑战.
- 在临床和植物相关的Fusarium菌株中观察到交叉阿醇耐药性,这引发了对治疗疗效的担忧.
研究的目的:
- 审查由Fusarium物种引起的人类疾病的频谱.
- 探索Fusarium中阿醇耐药性的潜在遗传基础.
- 讨论侵袭性菌病报告不足的原因.
主要方法:
- 临床Fusarium分离物的药物概况.
- 审查关于虫病和醇耐药性的现有文献.
- 临床频谱偏差和潜在遗传机制的分析.
主要成果:
- 临床Fusarium分离物表现出对前线抗真菌药物的耐药性,包括交叉阿醇耐药性.
- 在临床环境中对醇耐药机制的遗传证据有限.
- 与角膜炎和阴茎菌病相比,侵入性菌病在全球范围内报告不足.
结论:
- 菌的高优先级地位是由广泛的抗真菌耐药性驱动的.
- 了解阿醇耐药性的遗传基础对于开发有效的治疗方法至关重要.
- 需要进一步的研究,以准确报告和管理侵袭性融合症.
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