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在炎症性肠病研究中存储肠道活检:一项丹麦全国性基于人口的注册研究
Heidi Lynge Søfelt1, Jessica Pingel1,2, Donna Lykke Wolff3,4
1Molecular Diagnostics and Clinical Research Unit, Department of Internal Medicine, University Hospital of Southern Denmark, 6200 Aabenraa, Denmark.
Journal of personalized medicine
|April 25, 2025
概括
大多数炎症性肠病 (IBD) 患者可获得肠道活检,这是识别新药候选人和生物标志物的宝贵资源,以推进个性化医疗.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 个性化医疗是个性化的医疗.
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),影响肠道,许多患者目前的治疗方法不足.
- 现有的IBD治疗方法具有显著的副作用,需要个性化医疗方法.
- 归档的肠道活检和现实世界的数据为发现新的IBD药物候选物和生物标志物提供了潜力.
研究的目的:
- 评估用于研究的IBD患者储存的甲固定,嵌 (FFPE) 肠道活检的可用性.
- 评估结合真实世界数据与存档的生物样本用于IBD研究的可行性.
主要方法:
- 利用了丹麦国家患者登记册和丹麦病理学登记册的数据.
- 构建了2005年1月至2013年6月期间诊断的IBD患者队列,随访时间为5年.
- 分析了活检数据,包括诊所的位置和次数,与疾病严重程度相关.
主要成果:
- 在14,512名IBD患者中,96%的患者在诊断后五年内至少进行了一次活检 (CD 94%,UC 97%).
- 94%的患者在诊断过程中进行了第一次活检,主要是从结肠 (82%).
- 与不严重的IBD患者相比,患有严重IBD的患者进行了更多的活检检查.
结论:
- 绝大多数IBD患者有活检可用于研究目的.
- 将现实世界的数据与存档的肠道活检相结合,对于IBD研究来说是可行的和有价值的.
- 归档的活检代表了一个未充分利用的资源,具有显著的潜力,用于识别新的候选药物,生物标志物,并推进个性化的IBD医学.
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