在胃癌患者内镜切除和手术切除后便微生物组的比较变化
Hochan Seo1,2, Jae Yong Park2, Hee Sang You1,2
1Laboratory of Gastrointestinal Mucosal Immunology, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea.
Journal of personalized medicine
|April 25, 2025
概括
胃癌治疗显著改变了肠道微生物群. 手术胃切除术大大减少了微生物的多样性,而内镜下粘膜剖析 (ESD) 对胃肠道微生物群的影响很小.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 在瘤学瘤学.
背景情况:
- 胃癌治疗可以对胃肠道微生物群产生深远的影响.
- 胃切除术与内镜下粘膜切割 (ESD) 对微生物群的差异性影响尚不清楚.
研究的目的:
- 研究胃切除术和ESD对第一阶段胃癌患者微生物多样性和组成的影响.
- 为了比较由手术切除和内镜治疗引起的微生物组变化.
主要方法:
- 16S rRNA基因测序用于分析13名第一阶段胃癌患者 (5 ESD, 8 胃切除术) 治疗前后的便样本.
- 评估了微生物多样性指数 (α和β多样性) 和分类构成.
- 随访延长至治疗后两年.
主要成果:
- 总的来说,治疗后的微生物组分析显示,α多样性显著下降,β多样性明显聚类.
- 细菌菌的数量减少,而乳杆菌,双菌和蓝菌在整个队列中增加.
- 胃切除术显著减少了α多样性和改变了β多样性,增加了链球菌和蓝性菌,同时减少了细菌菌;ESD对α多样性的影响最小,但改变了β多样性.
结论:
- 手术胃切除术显著影响肠道微生物群的多样性和组成.
- 内镜下粘膜剖析 (ESD) 对微生物群的影响相对有限.
- 在胃癌患者的术后治疗中,应考虑微生物组调制.
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