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慢性病患者的阿迪波涅丁和全因死亡率:系统性审查和元分析

Hyun Suk Yang¹, Soo-Nyung Kim², Jung-Hoon Ro³

¹Department of Cardiovascular Medicine, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul 05029, Republic of Korea.

|April 25, 2025

概括

慢性脏病 (CKD) 中阿迪波涅丁水平升高显示出各种死亡风险. 预后值取决于患者子组,表明性别和BMI等因素调节结果.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
内分泌学在内分泌学.
流行病学流行病学

背景情况:

在慢性病 (CKD) 中,阿迪波涅丁水平升高与增加的死亡率有悖论的联系.
了解这种关联对于CKD患者的风险分层至关重要.

研究的目的:

评估循环阿迪波涅克丁水平与CKD患者全因死亡率之间的关联.
在各种CKD患者小组中分析这种关联.

主要方法:

在PubMed,Embase和Cochrane图书馆进行系统搜索,直到2024年12月.
包括12项研究,包括2523名CKD患者 (第2-5阶段) 报告了基线腺素和所有原因死亡风险比率 (HRs).
随机效应对HRs的元分析,每增加1μg/mL的腺素.

主要成果:

综合所有原因死亡率的整体未调整HR为1.003 (95%CI:0.981-1.025).
在非亚洲亚组中观察到增加的死亡风险,研究中女性<47%,BMI≥25 kg/m2.
死亡风险降低与腹腔透析患者和研究中子透析患者的子透析水平较高和女性≥47%的死亡风险相关.

结论:

在CKD亚组中,增加的阿迪波涅丁水平与全因死亡风险呈现异质的关联.
人口和临床因素,如性别和BMI,调节了CKD中阿迪波涅丁的预后价值.
限制包括早期CKD的代表性不足,影响了概括性.

关键词:

没有任何的Adiponectin.所有原因的死亡率.慢性脏疾病慢性脏疾病血液透析是血液透析的方法之一.腹膜透析是指腹膜透析.

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