从有药物使用史的捐赠者获得肺移植
David Li1, Justin Weinkauf2, Alim Hirji2
1Department of Medicine, University of British Columbia, Vancouver, Canada.
Clinical transplantation
|April 25, 2025
概括
捐赠物质的使用在肺移植中很常见,但通常不会伤害接受者. 捐赠者的大量吸烟增加了风险,但其他物质的使用没有对肺部全移植生存产生负面影响.
科学领域:
- 移植免疫学 移植免疫学
- 肺部医学 肺部医学
- 毒理学 毒理学 毒理学
背景情况:
- 肺移植捐赠者中使用物质很普遍.
- 人们对使用捐赠物质可能造成的移植损伤存在担忧.
- 特定的药物,如兴奋剂和吸烟物质,可以导致肺病理.
研究的目的:
- 分析肺移植接受者的捐赠物质使用模式.
- 评估供体物质使用对受体生存和移植功能障碍的影响.
- 调查与慢性肺异位移植功能障碍 (CLAD),严重初级移植功能障碍 (PGD3) 和基线肺异位移植功能障碍 (BLAD) 的关联.
主要方法:
- 2004-2016年双重肺移植接受者的回顾性研究.
- 分析包括有使用九种预先指定物质的捐赠者.
- 统计模型评估了与死亡,再移植,CLAD,PGD3和BLAD的关联.
主要成果:
- 39%的接受者从有毒物质使用史的捐赠者那里获得肺部.
- 没有发现捐赠物质使用与不良结果之间的总体关联.
- 沉重的供体吸烟与死亡/再移植,PGD3和BLAD的风险增加有关.
- 捐赠者使用可卡因与更糟糕的生存率有关,但不是CLAD或BLAD.
- 没有任何药物使用与CLAD相关.
结论:
- 捐赠物质的使用频繁,通常不会使肺移植结果恶化.
- 沉重的供体吸烟是一个例外,与较差的生存率和增加的移植功能障碍有关.
- 结果可以为供体选择和移植后管理策略提供信息.
相关概念视频
Tissue Transplantation
271
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
271
Bone Marrow Sampling and Transplants
260
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
260
Pulmonary Tuberculosis I
205
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
205


