相关实验视频

Updated: May 10, 2025

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

血造干细胞翻译用于牛皮的复发. 系统性审查系统性审查

Wenqiu Wang^1,2, Rui Wang², Chengxin Li³

¹Medical School of PLA General Hospital, Beijing, 100853, China.

Archives of dermatological research

|April 25, 2025

概括

血造干细胞移植 (HSCT) 在大多数患者中有效治疗了牛皮,75.6%的患者没有复发. 这为治疗这种慢性自身免疫性疾病提供了一个有前途的新疗法选择.

科学领域:

免疫学免疫学免疫学
皮肤病学皮肤病学
血液学血液学血液学

背景情况:

牛皮是一种慢性,全身性自身免疫性疾病,复发率高,需要新的治疗方法.
造血干细胞移植 (HSCT) 是一种已被认可的治疗血液性恶性瘤的疗法.
临床观察表明,HSCT可以有效控制患有同时存在血液瘤的患者的牛皮.

研究的目的:

系统地审查HSCT在治疗牛皮和预防其复发方面的疗效.
评估HSCT在牛皮管理中的潜在免疫调节活性.

主要方法:

在2023年5月31日之前发表的研究的系统文献综述,来自PubMed,Cochrane图书馆,WOS,CNKI和万芳数据库.
包括对12岁以上的患有血液性恶性瘤和接受HSCT的牛皮的患者进行的临床研究.
排除动物模型,hMSC移植,叙事评论和写给编辑的信件;使用Joanna Briggs Institute (JBI) 标准进行质量评估.

主要成果:

包括包括41名患者的20篇文章 (33名男性,8名女性;年龄在12-67岁之间).
大多数研究 (4级证据) 符合质量标准 (≥50%的JBI项目).
总的来说,75.6% (31/41) 的患者在随访期间 (长达264个月) 没有出现牛皮复发;24.4% (10/41) 的患者出现了复发,通常严重程度或分辨率有所改善.

结论:

造血干细胞移植 (HSCT) 显示出作为有效治疗牛皮和预防其复发的重要前景.
需要进一步进行严格的流行病学研究,以充分阐明HSCT对更广泛的牛皮患者群体的益处.
HSCT的免疫调节作用有助于其在治疗牛皮的有效性.

关键词:

细胞移植细胞移植造血干细胞移植造血干细胞移植牛皮病是什么意思牛皮病复发复发的情况系统性审查系统性审查

更多相关视频

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications

Published on: August 9, 2022

相关概念视频

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...