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作为S100A7作为一个预测生物标志物在恶性转化口腔上皮质发育不良的病变

Jeffrey Soparlo¹, Lachlan McLean¹, Christina McCord¹

¹University of Western Ontario, London, ON, Canada.

Discover oncology

|April 25, 2025

概括

S100A7蛋白水平可以帮助识别患有口腔状细胞癌 (OSCC) 高风险的口腔潜在恶性疾病 (OPMD). 这种生物标志物有助于区分转化和非转化OPMD.

科学领域:

口腔病理学口腔病理学
发现生物标志物的发现.
癌症研究癌症研究

背景情况:

在与口腔状细胞癌 (OSCC) 转变相关的口腔潜在恶性疾病 (OPMD) 中,S100A7表达升高.
了解S100A7的作用对于早期检测和干预至关重要.

研究的目的:

评估在OPMD中S100A7表达的进展到OSCC的情况.
为了将S100A7水平与已建立的生殖不良分级系统相关联.
评估基于S100A7免疫组织化学算法 (S100A7 ARS) 的风险分层.

主要方法:

分析了48个转化OPMD,35个非转化OPMD和25个对照对象的甲固定嵌标本.
使用免疫组织化学检测S100A7蛋白表达.
采用S100A7 ARS的半定量评分和图像分析.

主要成果:

半定量的S100A7得分与S100A7的ARS有很强的相关性.
这两种方法都有效地将OPMD与对照组区分开来.
S100A7 ARS区分了转化为癌症的OPMD和没有转化为癌症的OPMD (p <0.05).

结论:

S100A7免疫组织化学染色显示,有望用于识别高风险OPMD.
S100A7 ARS是预测OPMD恶性转变风险的一个有价值的工具.

关键词:

免疫组织化学免疫组织化学口腔上皮质发育不良症口腔状细胞癌的癌症.在 S100A7A7 中使用.

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