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在女性生殖系统中Ga-FAPI-04的生理吸收⁶⁸

Jingshi Mu¹, Yue Zhang¹, Yuxiao Xia²

¹Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Molecular imaging and biology

|April 25, 2025

概括

-68纤维细胞激活蛋白抑制剂 (68Ga-FAPI-04) 在绝经前妇女的生殖器官中比绝经后妇女吸收更高. 积累随月经周期而变化,并且随着年龄的增长而减少.

科学领域:

核医学是一种核医学.
放射性药理学是一种放射性药理学.
妇科瘤学成像检查妇科瘤学成像检查

背景情况:

用-68 (68Ga-FAPI-04) 标记的纤维细胞激活蛋白抑制剂 (FAPI) 越来越多地用于PET/CT成像.
之前的观察发现68Ga-FAPI-04在女性生殖器官中被大量吸收,这促使对其生理特征进行进一步调查.

研究的目的:

研究68Ga-FAPI-04在女性生殖器官中的生理吸收特征.
为了确定68Ga-FAPI-04在这些器官中吸收的初步参考范围,以潜在的临床应用.

主要方法:

在2022年4月至2023年6月期间接受68Ga-FAPI-04 PET/CT治疗的109名女性患者的回顾性评估.
收集了生殖器官和患者月经状况的标准摄取值 (SUV).
为了进行比较分析,将患者分为生殖,绝经前期和绝经后期的组.

主要成果:

与绝经后患者相比,在生殖年龄的患者中观察到较高的卵巢SUV.
子宫SUV在 fundus和corpus中大约高出子宫的三倍.
生殖器官SUV (卵巢除外) 与年龄有显著的负相关性 (p < 0.01).
卵巢和子宫吸收随月经周期阶段而变化,在排卵期间观察到更高的SUV分别在卵巢和月经/生殖阶段早期.

结论:

68Ga-FAPI-04在女性生殖器官中的吸收在绝经前妇女中高于绝经后妇女.
这些器官中68Ga-FAPI-04的积累似乎受到月经周期的影响.
建议对不同月经阶段的更大队列进行进一步的研究,以阐明吸收机制.

关键词:

68Ga-FAPI-04的使用情况卵巢卵巢卵巢卵巢在这里,PET是PET.生理学吸收时间在子宫,子宫.

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