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Updated: May 10, 2025

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
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在LRRK2-帕金森病模型中,溶酶体TPC2通道破坏了Ca2+进入和多巴胺功能

Martina Gregori1, Gustavo J S Pereira1,2, Robert Allen3

  • 1Department of Cell and Developmental Biology, University College London, London, UK.

The Journal of cell biology
|April 25, 2025
PubMed
概括

帕金森病涉及神经元退化. 这项研究揭示了 (Ca2+) 进入和 lysosomal 功能之间的联系,确定 TPC2 作为帕金森病的潜在治疗点.

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