探索肠道微生物群和精神分裂症患者的认知功能之间的关系,这些患者有不同的体重
Baoyuan Zhu1, Liqin Liang2, Yuanyuan Huang3
1School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 511442, China.
Schizophrenia research
|April 25, 2025
概括
精神分裂症 (SZ) 患者表现出改变的肠道微生物群,特别是在那些超重/肥胖 (OW) 患者中. 特定的细菌变化与认知功能相关,这表明肠道健康影响SZ认知缺陷.
科学领域:
- 微生物组研究 微生物组研究
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
背景情况:
- 精神分裂症 (SZ) 与肠道微生物群失调和认知障碍有关.
- 身体质量指数 (BMI) 可能会影响SZ患者的肠道微生物组合.
研究的目的:
- 为了研究不同BMI类别 (超重/肥胖[OW]与正常体重[NW]) 的SZ患者的肠道微生物组成.
- 探索肠道微生物群落,认知功能和SZ中的代谢途径之间的关联.
主要方法:
- 来自156名SZ患者和156名正常对照 (NC) 的16SrRNA测序数据的分析,按BMI分层.
- 在SZ和NC组之间比较微生物多样性和组成.
- 微生物群落与临床症状和认知功能的相关性分析;代谢途径的检查.
主要成果:
- 与NC相比,在SZ患者中观察到不同的肠道微生物群概况,根据BMI而异.
- 在SZ患者中,增加的Collinsella与认知功能有负相关,而减少的Clostridium和Butyricicoccus与认知功能有正相关.
- 在SZ_OW组中发现的"其他氨基酸代谢"和"神经退行性疾病"途径的丰富.
结论:
- 在SZ患者和对照人群之间存在肠道微生物群的显著差异,以BMI调节.
- 特定的肠道细菌和代谢途径与SZ患者的认知功能有关,特别是那些患有肥胖症的人.
- 研究结果提供了关于肠-大脑轴机制的见解,这些机制是精神分裂症与肥胖症的认知缺陷的基础.
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