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相关概念视频

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

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相关实验视频

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解读聚米辛B的固态光稳定性,使用基于解卷的FTIR洞察力.

Aanchal Yadav1, Pavankumar Sathala2, Madhuri Divate2

  • 1Department of Biopharmaceuticals, National Institute of Pharmaceutical Education and Research- Guwahati (NIPER-G), Guwahati assam, India 781101.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
|April 25, 2025
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概括

聚米辛B抗生素在暴露于光线,特别是紫外线时迅速降解. 在各种照明条件和室温下分析了结构变化和降解率,揭示了其区的特定分解模式.

关键词:
循环-七类的骨干是循环-七类.降解降解是一种降解.脂肪酸尾巴的脂肪酸尾巴.摄影稳定性 摄影稳定性波利米克辛B是一种多重的物质.这是一种三类.不复杂的FT-IR是什么?

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科学领域:

  • 分析化学 分析化学
  • 频谱学是一种光谱学.
  • 制药科学 制药科学

背景情况:

  • 聚米辛B是一种具有已知的不稳定性问题的关键抗生素.
  • 它的固态光稳定性需要彻底调查,因为易于降解.
  • 了解降解途径对于有效的储存和配方至关重要.

研究的目的:

  • 为了研究Polymyxin B.的固态光稳定性.
  • 为了阐明室温,紫外线和可见光下的结构变化.
  • 确定降解动力学和确定脆弱区域.

主要方法:

  • 采用了基于解卷的里叶变换红外光谱法 (FTIR).
  • 分析了五个定义的光谱区域的结构变化.
  • 在不同的光照条件下,对30天的光稳定性进行了评估.
  • 主要组件分析 (PCA) 用于分析降解趋势.

主要成果:

  • 循环-七片区的碎片化率最高,特别是在紫外线下.
  • 降解在室温下遵循二次动力学,在暴露于光线下更高.
  • 紫外线光主要降解键,而可见光则导致基组氧化.
  • 脂肪乙尾表现出对水解反应的更大稳定性.

结论:

  • 聚米辛B在其功能区域中呈现差异性降解.
  • 与室温相比,紫外线和可见光显著加快了降解速度.
  • 室温退化在特定区域遵循零级动力学,由光照强化.
  • 提供了关于Polymyxin B在各种条件下的稳定性的见解.