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大麻种子蛋白通过降解成短来发挥其低血糖和低脂作用

Mingchen Liu¹, Yicheng Li², Wentao Li¹

¹College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China; Chinese Medicinal Materials Breeding Innovation Center, Yuelushan Laboratory, 410128, China.

|April 25, 2025

概括

大麻种子蛋白 (HSP) 通过抑制消化酶和调节关键代谢途径,改善葡萄糖和脂质代谢. HSP中的生物活性显示出功能性健康食品的潜力.

科学领域:

营养科学营养科学
生物化学生物化学
代谢健康代谢健康

背景情况:

肥胖和代谢障碍是全球重要的健康问题.
饮食中的蛋白质越来越多地被认为是它们在代谢调节中的作用.
大麻种子蛋白 (HSP) 是一种植物性蛋白质来源,具有潜在的健康益处.

研究的目的:

研究大麻种子蛋白 (HSP) 对葡萄糖和脂质代谢的影响.
阐明HSP代谢调节效应的潜在机制.
探索HSP作为功能健康食品成分的潜力.

主要方法:

使用高脂肪诱导的小鼠肥胖模型来评估体内效应.
试验室试验评估了HSP及其化物对消化酶的抑制活性.
网络药理学和分子对接被用来识别生物活性和它们的标.

主要成果:

高粉补充剂显著降低血清总胆固醇 (TC),三糖化物 (TG) 和LDL-C,同时增加HDL-C.
肝脂积累减少,葡萄糖耐受性和胰岛素敏感性在体内得到改善.
在实验室中,HSP水解剂显示增强了胰腺α-氨酶和脂酶的抑制.
确定了三种生物活性大麻种子,与AKT1,PPARG和HMGCR相互作用.

结论:

高粉对葡萄糖和脂质代谢有显著的有益影响.
由HSP进行的代谢调节是由生物活性介导的.
这些通过抑制消化酶和调节AMPK-AKT1/PPARG/HMGCR通路而起作用.
作为改善代谢健康的功能成分,HSP具有前景.

关键词:

大麻种子的酸.大麻种子蛋白质大麻种子蛋白质.低血糖的影响低血糖效应低脂性效应低脂性影响分子对接是分子对接.网络药理学网络药理学肥胖的模型模型

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