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环境暴露于金属毒素作为结肠直肠癌的危险因素:一项案例对照研究

Sandy Kavalukas¹, Allie Jin², Olufunmilayo Babarinde³

¹Division of Colorectal Surgery, Hiram C. Polk Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky; Center for Integrative Environmental Health Sciences (CIEHS), University of Louisville School of Medicine, Louisville, Kentucky.

The Journal of surgical research

|April 25, 2025

概括

环境中的和暴露可能会增加结直肠癌 (CRC) 的风险. 这项试点研究发现,随着尿和的升高,CRC的几率更高,尽管结果在统计学上没有显著意义.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
癌症流行病学癌症流行病学

背景情况:

结肠直肠癌 (CRC) 是美国癌症死亡的主要原因.
环境毒素对CRC发病率的影响尚不清楚.
之前对和等致癌物质的研究主要集中在职业暴露,而不是一般的环境水平.

研究的目的:

调查个人环境中的和暴露与结直肠癌 (CRC) 发病率之间的关联.
在病例控制研究中使用生物标本来测量金属暴露.

主要方法:

进行了一项试点病例控制研究.
尿液和血液样本使用诱导联等离子体质谱学分析了和.
后勤回归模型估计了几率比率 (OR) 和95%置信区间 (CI),根据年龄,性别,家族史和吸烟状况进行调整.

主要成果:

这项研究分析了79个尿液和84个血液样本.
更高的尿水平与CRC的概率增加1.77倍 (95%CI:0.62-5.00) 相关.
尿中较高的含量与CRC的几率增加了1.90倍 (95%CI:0.68-5.31).
较高的血水平显示,CRC的几率增加了1.29倍 (95%CI:0.45-3.72).

结论:

这是第一个使用生物样本检查个人水平环境金属暴露和CRC发病率的研究.
试验结果表明潜在的积极关联,但在统计学上并不显著.
需要使用更大的样本大小进行进一步的研究来证实这些发现,并探索环境毒素在CRC中的作用.

关键词:

致癌物质是致癌物质.案件控制 - 案件控制.结肠直肠癌是一种癌症.环境环境环境环境金属金属金属

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