菲律宾塞布市一次性大规模登革热疫苗接种的有效性:为期5年的病例控制研究的最终结果
Kristal An Agrupis1, Maria Vinna Crisostomo1, Jedas Veronica Daag1
1Institute of Child Health and Human Development, University of the Philippines - National Institutes of Health, Manila, Philippines.
Vaccine
|April 25, 2025
概括
一次剂量的CYD-TDV登革热疫苗提供了针对严重登革热表现的延长保护. 这项研究评估了菲律宾塞布的儿童疫苗的有效性,直到2023年2月.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 菲律宾于2017年中期在塞布省启动了一项使用CYD-TDV (Dengvaxia) 的登革热疫苗接种计划,针对9-14岁的儿童.
- 该计划在一次剂量后被停止,临时疫苗有效性数据可用到2020年.
研究的目的:
- 评估一剂CYD-TDV疫苗在2023年2月之前对登革热的延长疫苗保护.
- 在程序中断后,在现实环境中评估疫苗的有效性.
主要方法:
- 从2018年2月到2023年2月,在塞布省进行了一项病例控制研究.
- 被怀疑登革热住院的儿童被录取,与邻居对照相比,他们的疫苗接种情况.
- 登革热病毒血清型通过RT-PCR识别,并使用世卫组织2009年标准对疾病严重程度进行分类.
主要成果:
- 这项研究包括584例病毒学证实登革热病例和1168例对照病例.
- 一剂CYD-TDV对住院VCD的保护率为21%,对更严重的登革热表现 (具有警告迹象的登革热和严重的登革热) 的保护率为31%.
- 登革热病毒血清型3是最常见的 (49.1%).
结论:
- 一次剂量的CYD-TDV提供了持续的保护,防止严重的登革热后果.
- 该研究的局限性包括缺乏基线登革热血清状态数据,尽管大多数参与者在接种疫苗之前可能是血清阳性.
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