环境PM2.5暴露,体力活动和心血管功能障碍:查尔斯数据分析和小鼠实验研究的分析
Hao Chang1, Kun Pan2, Xi Zhang3
1State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen 361102, China.
Journal of hazardous materials
|April 25, 2025
概括
长期暴露于细颗粒物 (PM2.5) 增加了心血管疾病的风险,但定期体力活动提供了保护. 运动可以帮助减轻PM2.5的风险.
科学领域:
- 环境健康科学 环境健康科学
- 心血管研究研究心血管研究
- 分子毒理学 分子毒理学
背景情况:
- 环境细颗粒物 (PM2.5) 是已知的心血管疾病 (CVD) 风险因素.
- 关联PM2.5暴露与心血管疾病的分子机制尚未完全理解.
- 身体活动对PM2.5危害的心脏保护作用需要进一步研究.
研究的目的:
- 研究长期PM2.5暴露,体力活动和心血管健康之间的关联.
- 探索PM2.5引起的心血管损伤和体力活动减轻影响的分子机制.
主要方法:
- 中国健康与退休长度研究 (CHARLS) 数据的流行病学分析.
- 使用C57BL/6雄性小鼠在定期体力活动或静坐条件下暴露于PM2.5或过空气 (FA) 的实验研究2-6个月.
- 进行了生物化学测定,脂质组学和蛋白质组学分析.
主要成果:
- 长期暴露于PM2.5显著增加了心血管疾病的风险;身体活动显示出保护作用,部分减轻了PM2.5对心脏病和失脂症的不良影响.
- 暴露于PM2.5的小鼠表现出血压升高,阿迪波金和脂质概况受损,以及线粒体损伤,所有这些都因体力活动而部分改善.
- PM2.5破坏了脂质代谢和蛋白质调节通路;体力活动通过调节脂质代谢,凝血和免疫反应来减轻这些.
结论:
- 定期体力活动对心血管健康至关重要,可以部分抵消PM2.5暴露的有害影响.
- 研究结果强调了将体育活动纳入预防心血管疾病的公共卫生战略的重要性.
- 优先考虑PM2.5减少措施对于减轻心血管疾病负担至关重要.
相关概念视频
Transmission-based Precautions II: Airborne and Protective Environment
1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K
Factors Affecting Pulmonary Ventilation
967
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
967
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Atomic Absorption Spectroscopy: Atomization Methods
305
Atomic Absorption Spectroscopy (AAS) atomizes samples through flame atomization or electrothermal atomization. Flame atomization typically involves a nebulizer and spray chamber assembly to combine the sample with a fuel–oxidant mixture, creating a fine aerosol mist that enters a burner. Typically, the fuel and oxidant are combined in an approximately stoichiometric ratio. However, for atoms that are easily oxidized, a fuel-rich mixture may be more advantageous. Only about 5% of the...
305
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
Chronic Obstructive Pulmonary Disease
1.1K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.1K


