Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

26
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
26
Cancer Therapies02:49

Cancer Therapies

7.4K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.4K
Bioremediation00:46

Bioremediation

18.1K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
18.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Lattice peak optimization: a mixed-integer framework for geometry-adaptive lattice radiotherapy.

Physics in medicine and biology·2026
Same author

Feasibility of proton ultra-high-dose-rate spatially fractionated radiotherapy system for preclinical experiments on a compact proton synchrocyclotron.

Physics in medicine and biology·2026
Same author

Equivalent-Uniform-Dose Optimization for Spatially Fractionated Radiation Therapy.

Technology in cancer research & treatment·2025
Same author

Feasibility of prototype diamond detectors for pulsed UHDR PBS small-field proton dosimetry for proton FLASH experiments.

Physics in medicine and biology·2025
Same author

A predictive model studying the impact of timing and order for the combination-regime of spatially fractionated radiation therapy and stereotactic body radiation therapy.

Physics in medicine and biology·2025
Same author

Optimizing normal tissue sparing via spatiotemporal optimization under equivalent tumor-radical efficacy.

Physics in medicine and biology·2025

相关实验视频

Updated: May 10, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
06:24

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

9.9K

一种生物优化方法用于碳疗法通过代的雅可比式基于线性化.

Chao Wang1, Ya-Nan Zhu1, Wangyao Li1

  • 1Department of Radiation Oncology, University of Kansas Medical Center, Kansas, KS, United States of America.

Physics in medicine and biology
|April 25, 2025
PubMed
概括
此摘要是机器生成的。

一种新的代雅可比式线性化 (IJL) 方法通过准确高效地优化生物剂量来改进碳离子放射治疗 (CIRT) 规划,从而更好地控制瘤并减少正常组织损伤.

关键词:
生物剂量是生物剂量.碳疗法是一种碳疗法.相反的优化反向优化微粒疗法是一种微粒疗法.治疗计划 治疗计划

更多相关视频

Optimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations
14:33

Optimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations

Published on: October 1, 2013

14.3K
Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria
08:33

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria

Published on: July 28, 2023

510

相关实验视频

Last Updated: May 10, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
06:24

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

9.9K
Optimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations
14:33

Optimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations

Published on: October 1, 2013

14.3K
Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria
08:33

Author Spotlight: An Optimized Automated Method for Investigating Retinoic Acid Receptors in Neuronal Mitochondria

Published on: July 28, 2023

510

科学领域:

  • 医学物理 医学物理
  • 辐射瘤学 辐射瘤学
  • 计算生物学 计算生物学

背景情况:

  • 与光子或质子疗法相比,碳离子辐射疗法 (CIRT) 对放射性耐药瘤提供了更高的生物学有效性.
  • 在CIRT中优化生物剂量对于最大化瘤杀伤效应至关重要,同时最大限度地减少对周围正常组织和有风险的器官 (OAR) 的损害.
  • 现有的CIRT生物剂量优化方法面临着由于非线性生物剂量模型的数学挑战,导致计算效率低下和不准确.

研究的目的:

  • 为碳离子放射治疗 (CIRT) 开发一种准确有效的生物剂量优化方法.
  • 解决CIRT中非线性生物剂量模型所带来的计算挑战.
  • 通过增强瘤杀伤剂剂量输送和OAR节省来改善治疗规划.

主要方法:

  • 在CIRT中引入了代的基于Jacob的线性化 (IJL) 方法,用于生物剂量优化.
  • 使用物理剂量和相对生物效应的乘积来建模生物剂量,基于线性二次和局部效应模型.
  • 采用代凸放松,用雅可比式近似对非线性生物剂量进行线性化,并通过乘数的交替方向方法 (ADMM) 解决子问题.
  • 将IJL与有限内存的准牛顿 (QN) 方法进行比较,该方法直接解决了非线性优化问题.

主要成果:

  • 与QN方法相比,IJL表现出更高的计划准确性,通过改进的OAR节省证明了这一点.
  • 在围绕临床目标体积 (CTV) 的规划目标体积1cm (PTV1cm) 中的生物剂量减少到89.7% (大脑),95.0% (肺) 和88.3% (腹部) 的IJL.
  • 与QN相比,IJL的计算效率显著提高,每次代需要大约1/10的计算时间.
  • IJL显示了持续下降的目标函数,而QN方法在一定数量的代后停滞不前.

结论:

  • 新型代的基于雅可比式线性化 (IJL) 算法准确有效地解决了CIRT的生物优化问题.
  • 在规划准确性和计算效率方面,IJL比QN等直接非线性优化方法具有显著的优势.
  • 这种方法有助于推进CIRT治疗计划,使得癌症治疗更精确,更有效.