甲型类型与未经控制的儿童喘,肠道微生物群和全身炎症有关
Mahmoud I Abdel-Aziz1, Simone Hashimoto2, Anne H Neerincx3
1Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Institute for Infection and Immunity, Inflammatory Diseases, Amsterdam, The Netherlands; Amsterdam Public Health, Personalized Medicine, Amsterdam, The Netherlands; Department of Clinical Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
儿童喘元型与疾病控制和肠道细菌有关. 这些发现支持使用metabotyping进行个性化喘治疗策略.
科学领域:
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
- 儿童喘 在儿童喘中
背景情况:
- 儿童喘与独特的代谢概况有关.
- 了解这些特征可以有助于喘管理.
研究的目的:
- 在中度至重度喘儿童中识别不同的代谢表型 (代谢类型).
- 使用综合性便和血清代谢组分析进行表型化.
主要方法:
- 全球喘倡议 (GINA) 招募儿童治疗步骤3+喘.
- 进行了针对性的便和血清代谢分析.
- 综合数据使用相似性网络融合和光谱聚类.
主要成果:
- 在92名儿童中确定了3种不同的元类型.
- 代谢类型2与更好的喘控制,更高的母乳养率和特定的脂质配置文件相关.
- 代谢型3与失控的喘,改变肠道微生物群多样性和特定代谢物变化有关.
结论:
- 喘元型与喘控制,肠道微生物组成和全身炎症相关.
- 转型类型学显示出在儿科喘中精准医学的前景.
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