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在大鼠中,epigoitrin 降低了突触体中谷氨酸释放,并保护神经元免受谷氨酸刺激毒性的作用

Yi Chang¹, Wun-Jing Pan², Su-Jane Wang³

¹School of Medicine, Fu Jen Catholic University, New Taipei City, 24205, Taiwan; Department of Anesthesiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 22060, Taiwan.

European journal of pharmacology

|April 25, 2025

概括

在Radix isatidis中发现的epigoitrin,通过抑制P/Q型通道,氧化应激和神经炎症来降低过度的谷氨酸释放,并通过抑制P/Q型通道,氧化应激和神经炎症来防止刺激毒性.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

过度的突触谷氨酸酸会导致刺激毒性和神经病理.
拉迪克斯伊萨蒂迪斯含有epigoitrin,一种潜在的神经保护剂.

研究的目的:

为了研究表皮素对大鼠皮质突触体中谷氨酸释放的作用.
为了评估epigoitrin在老鼠中的神经保护作用,以防止酸诱导的兴奋毒性.

主要方法:

评估了Epigoitrin对隔离的老鼠皮质突触体中的谷氨酸释放的剂量依赖作用.
在体内使用大鼠模型来检查酸诱导的神经毒性.
测量了神经元损伤,蛋白质表达,氧化应激标志物和炎症性细胞因子.

主要成果:

通过P/Q类型的Ca2+通道抑制了epigoitrin的谷氨酸释放 (IC50 = 3μM).
用epigoitrin进行预治疗显著减少了因甲酸诱导的神经元损伤,谷氨酸升高和DAPK1/GluN2B上调.
皮素降低了活性氧物种 (ROS),质激活和促炎细胞因子,同时增加了IL-10.

结论:

皮戈伊特林通过调节P/Q型Ca2+通道来抑制突触体中谷氨酸酸释放.
皮戈伊特林通过减轻氧化应激,神经炎症和谷氨酸激发毒性来提供对激发毒性的神经保护.
这项研究是第一个证明了表皮质素对谷氨基酶系统的影响的研究.

关键词:

皮层皮层皮层皮戈伊特林 (Epigoitrin) 是一种具有性作用的药物.谷氨酸酸盐的使用方法卡因酸是一种酸.神经保护是一种神经保护.突触体突触体是一个突触体突触体.

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