从临床样本中分离出来的Neisseria perflava可以减少流感病毒在呼吸道细胞中的复制

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Nasal Wipes for Influenza A Virus Detection and Isolation from Swine

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Published on: December 4, 2015

Keisuke Nishioka¹, Maki Nakagawa¹, Yoko Tanino²

¹Department of Infectious Diseases, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Journal of oral biosciences

|April 25, 2025

概括

一些口腔细菌,特别是Neisseria物种,可以直接抑制呼吸道细胞中的病毒复制. 这一发现表明口腔微生物群与宿主防御病毒感染之间的直接联系.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
病毒学病毒学

背景情况:

口腔是复杂的微生物群的所在地,其中包括Neisseria物种.
开始性口腔细菌对病毒感染易感性的直接影响尚不清楚.

研究的目的:

研究口服内菌物种对呼吸道细胞易受病毒感染的影响.
探索口腔细菌在调节对病毒的免疫反应方面的潜力.

主要方法:

从人类唾液中分离了六种尼塞利亚菌种.
在病毒挑战之前,用细菌培养超级生物刺激上皮细胞系.
评估病毒易感性和复制性的变化.

主要成果:

来自两个Neisseria物种的超活体抑制了流感病毒的复制.
抑制作用与10-30 kDa范围内的蛋白质有关.
同时,SARS-CoV-2和人类犀利病毒的复制也被抑制,而初始感染和细胞因子产生仍然不受影响.

结论:

暴露于特定的口腔细菌直接影响邻近细胞的病毒感染结果.
尼塞利亚菌种可以通过涉及基因表达的机制抑制病毒基因组复制.
需要进一步的研究才能充分阐明这种观察到的抗病毒效应背后的分子机制.

关键词:

这是天生的免疫力.微生物组是一个微生物组.支持性口腔护理是一种口腔护理.病毒学病毒学

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