在五个发育群体中,对外化和行为结果的遗传责任与跨越幼儿时期到早期成年期的行为结果之间的关联
Maia Choi1, Holly E Poore1, Sarah J Brislin1
1Rutgers University, New Jersey.
概括
对外化行为的遗传倾向与各种各样的问题有关,包括冲动性,行为问题和从童年到成年早期的物质使用. 这种遗传责任可以为未来的预防和干预策略提供信息.
科学领域:
- 行为遗传学 行为遗传学
- 发展心理学 发展心理学
- 精神病学遗传学 精神病学遗传学
背景情况:
- 了解外化行为的遗传风险因素对于开发有效的预防和早期干预策略至关重要.
- 对外化行为的遗传责任在整个生命周期内表现出来,从婴儿期到成年早期.
研究的目的:
- 描述与对外化的遗传责任相关的行为表现的发展轨迹.
- 检查外部化 (EXTPGS) 的多基因分数与6个月至26岁的相关表型之间的关联.
主要方法:
- 利用了来自外部化行为的大规模全基因组关联研究 (GWAS) 的多基因分数 (PGS).
- 分析了来自3个国家的5个基于人口和家庭的数据集的数据,从幼儿时期到早期成年期.
- 估计EXTPGS与表型之间的关联,包括冲动性,行为问题,ADHD,ODD和物质使用.
主要成果:
- EXTPGS与从幼儿时期到成年早期的广泛的外部化表型有显著的相关性.
- 较高的EXTPGS与增加的冲动性,行为问题以及ADHD和ODD的症状相关.
- 增加的物质使用和相关问题,包括酒精和非法药物使用,与从青春期早期到成年早期更高的EXTPGS有关.
- 观察到的性别特异性影响的证据很少.
结论:
- 对外化行为的遗传责任与各种行为,精神病和物质使用结果有关,在发育早期出现并持续到新兴的成年期.
- 这些相关行为的早期发病和广泛性强调了基因洞察力引导预防和干预工作的潜力.
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